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HIF-1α serves as the molecular linchpin, simultaneously upregulating VEGF while activating PI3K/Akt/mTOR and MAPK signaling cascades, thereby creating a feedforward loop that sustains tumor vascularization and progression (Figure 4) (Mabeta and Steenkamp, 2022

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doi: 10.1016/j.cell.2011.11.030

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