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Stable overexpression of the GLUT1 in primary human CAR-T cells enhances the secretion of pro-inflammatory cytokines, improves glucose uptake, and promotes T cell expansion and cytolytic capacity [138]

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More recent studies using VMAT2 and DA transporter radiotracers, which are more sensitive to early abnormalities than 18 F-DOPA PET, have estimated the initial decline in dopaminergic pre-synaptic activity to be up to 17 years before diagnosis