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Magnetic resonance imaging contrast agents undergo degradation in patients, transforming into toxic, electron-dense, intracellular nanoparticles We detected gadolinium-rich nanoparticles formed from systemic treatment with magnetic resonance imaging contrast agents ( Therefore, physiologic conditions substantially modify the chemical equilibration, lending to the dissociation of gadolinium from the ligand (Eq

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In particular, IGF-I receptor processing relies on this protease family, and so care must be taken to devise strategies for cleanly separating the actions of the PC family on ligand or receptor