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Potential adverse effects may include: Sedation Ataxia (hind limb weakness and coordination issues) Increased urination Gastrointestinal upset Nausea Vomiting Rare skin reactions If gastrointestinal discomfort occurs, administration with food or dividing the dose into multiple portions may help improve tolerance

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Thiamine pyrophosphate requirement for o-succinylbenzoic acid synthesis in Escherichia coli and evidence for an intermediate