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The mechanisms underlying this age-related NAD+ depletion involve multiple factors, including increased consumption by DNA repair enzymes, reduced biosynthesis, and enhanced degradation by CD38 and other NAD+-consuming enzymes

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However, these cancers could respond to (R)-9b, so we would like to investigate this drug in other solid tumors as well.” Mahajan said the drug spurs multiple responses because of the nature of the gene it blocks