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That breadth makes it the stronger candidate for questions involving: Insulin resistance and glucose uptake in skeletal muscle AMPK-dependent energy sensing under caloric restriction or exercise mimicry Mitochondrial stress responses and their systemic effects Age-related metabolic decline , given that circulating MOTS-c levels fall with age in humans For researchers already working with mitochondria-focused compounds, pairing MOTS-c with SS-31 (Elamipretide), a cardiolipin-targeting peptide, can help isolate whether an observed effect is driven by membrane integrity or by retrograde signaling

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But those studies, McGuire says, don’t have a lot of evidence behind them, and if you look on Reddit or other places where people are talking about it, he says, it appears that most people are recommending repeated doses