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Their finding marked a decisive breakthrough because it challenged a long-standing belief that nerves controlled the secretion of digestive enzymes that had grown out of the work of Ivan Pavlov, the Russian physiologist who demonstrated that dogs can be conditioned to salivate by the sound of a bell (Rehfeld 2012)

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F., et al., “Preventing Engrailed‐1 Activation in Fibroblasts Yields Wound Regeneration Without Scarring,” Science 372 (2021): eaba2374