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Previous studies further indicate that inhibiting IL-6 signaling significantly reduces neutrophil migration and infiltration, thereby mitigating local inflammation 28,29 , consistent with evidence that blocking IL-6 activity modulates innate immune cell recruitment and provides therapeutic targets for neuroinflammatory conditions 30

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Limited bioavailability and loss of folate during food processing and storage, and false nutrition or malnutrition, make the possibilities of reaching recommended targets for folate intake through food folates alone still rather uncertain