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Importantly, this study also showed that the higher MMA concentrations were only seen in elderly individuals with high folate and not in younger individuals, irrespective of folate concentration

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Preclinical research has explored plausible, reproducible effects on blood vessels, inflammation, fibroblast activity, gastrointestinal injury, and nerve recovery, and those findings define real areas of potential benefit worth testing, though animal data remains the main basis for the proposed benefits