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Cellular Senescence in Health, Disease, and Lens Aging[v1]

5-Amino-1MQ has been characterised across an expanding research literature spanning NNMT enzyme inhibition mechanism, adipocyte and obesity research, methyl-donor pool conservation, NAD+ pathway research, cancer-research framings (NNMT overexpression in tumours)

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243 During bleomycin-induced pulmonary fibrosis in mice, dysregulated lung microbiota, such as Bacteroides and Prevotella dyregulation, promotes the formation of fibrotic pathogens through IL-17R signaling and drive IL-17B production through their membrane vesicles, thereby promoting lung inflammation and fibrosis