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The better model for biologic IP cliff analysis distinguishes between interchangeable and non-interchangeable biosimilar entry, between therapeutic areas where physician inertia is high (oncology, immunology) and those where pharmacy substitution is more readily accepted (insulin analogs), and between markets with large commercial payer exposure (where PBM contracting is decisive) and those with high Medicare Part B exposure (where ASP-based reimbursement makes biosimilars structurally advantaged)

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