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The genetic deficiency of CYP2E1 rarely induced hepatic steatosis and oxidative stress in mice fed a high-fat Lieber–DeCarli liquid diet, whereas overexpression of CYP2E1 increased serum transaminases and accelerated other liver damages, such as upregulation of fibrosis markers including α-smooth muscle actin (α-SMA) and type I collagen, and elevated necroinflammation [104,148]

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Zn is important in the neonatal brain, due to its involvement in neurotransmission, synaptic plasticity, and neural signaling