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Final Discussion/Conclusions The literature included and reviewed here (Table 2) has used a variety of study designs, mainly of a retrospective type, but also there were some with overlapping LS populations (such as the GeoLynch cohort and the Colon Family Register), which could have led to further limitations regarding the small populations studied, hence conditioning and restricting data availability independence and putatively decreasing the ability to adjust for potential confounding factors [9]