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The unfolded UBL1 of FAT10 is then presented to the ATPase motor and, upon engagement and mechanical pulling, FAT10 is either released by NUB1 splaying out its domains or threaded through the NUB1 looped-out region

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Oxidative modifications of proteins and lipids will form danger or pathogen-associated molecular patterns in the immune system, which trigger chronic inflammation and the development of diabetes