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Subclinical hypothyroidism can be consistent with the above symptoms as well as a low basal body temperature (temp below 36.5 o C taken immediately upon waking, although this can also be affected by adrenal, immune and menstrual function) and the Achilles reflex test (slowed in hypothyroidism), as well as suboptimal blood results or auto-antibodies

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The Panel considered the TTC approach to conduct a risk assessment for the impurities o‐toluene sulfonamide, p‐toluene sulfonamide and benzoic acid p‐sulfonamide, as suitable based on the absence of compound‐specific toxicity data and given their lack of genotoxic potential

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