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To enhance sensitivity, specificity, and translational relevance, future research should incorporate multimodal biomarker strategies—combining imaging, fluid-based, and multi-omics analyses
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Mechanistically, the overexpression of GPX4 protects cells from mitochondrial pathway-mediated apoptosis by blocking mitochondrial release of CYCS, inactivating CASP3, and inhibiting hydroperoxide production [15,100,102–105] (Figure 5A)