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During this process, epithelial cells gradually acquire mesenchymal phenotypes (such as reduced intercellular adhesion and increased motility) in response to the microenvironment [94]

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Activated DCs undergo metabolic reprogramming, marked by increased glycolysis and reduced OXPHOS, and enhanced glycolysis activates the STING pathway, thereby boosting bone marrow-derived DC-mediated anti-tumor responses (246, 247)