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Vitamin B12 and insomnia have long been linked, however the research available remains inconclusive

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Intracellular Cu targets and binds to lipoylated components in the tricarboxylic acid (TCA) cycle, and aggregation of these Cu-bound lipoylated mitochondrial proteins—and the subsequent reduction in Fe–S (iron–sulfur) clusters—induces proteotoxic stress and ultimately cell death