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Figure 3] Evaluation of Blood-Brain Barrier (BBB) Penetration by Hybrid Exosomes [IMAGE] | EurekAlert! Science News Releases

Upon transcription, the unnatural splice site is incorporated into the nascent mRNA, resulting in early termination and functional deletion of the targeted gene, but unlike homozygous deletion techniques, some functional transcripts can be created due to missed splicing of the genetrap construct

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These fragments won't trigger HGF receptor binding or BDNF upregulation, but they'll still be eliminated via the same hepatic and renal pathways