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In the trial, nine patients with mild-to-moderate AD were injected with human umbilical cord blood-derived mesenchymal stem cells via stereotactic intraparenchymal surgical injection

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Black Box Warnings (abbreviated version): Because of the possibility of serious toxic (and potentially fatal) reactions, methotrexate should be used only in life threatening neoplastic diseases or severe recalcitrant psoriasis or rheumatoid arthritis which is not responsive to other forms of therapy