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With further research on the anti-tumor immune mechanism of the body, it is now well known that there are two main reasons for the abscopal effect of RT: (1) the lethal dose of irradiation induces immunogenic cell death (ICD) and (2) non-lethal dose irradiation induces immunoregulatory effects on tumor cells

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[DOI] [PubMed] [Google Scholar] 119.Patergnani S., Danese A., Bouhamida E., Aguiari G., Previati M., Pinton P., Giorgi C