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Beyond binding to the intended targets (e.g., TAA and CD3 for a TCE), additional engineering in the Fc region including point mutations in the Fc domain are also often incorporated in IgG-based approaches to inhibit Fcγ receptors (FcγR) I–III binding, improve PK (pharmacokinetics) by reducing liver uptake and eliminate antibody-dependent cell-mediated cytotoxicity (ADCC)

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10.1016/j.mcn.2013.03.003 24 JiangH.ShaS.-H

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