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(109) evaluated the effects of a preventive EODF regimen on the neurodegenerative phenotype of 5XFAD transgenic mice and found a significant increase in inflammation in the cortex of 5XFAD-EODF mice, with increased glial cell reactivity and/or proliferation, along with increased pro-inflammatory cytokines TNF- α , p38 MAPK, and EAAT2, and decreased GAD67, associated with glutamate excitotoxicity, and increased NMDA receptor subunit 2B in the cortex of 5XFAD-EODF mice

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In a trial involving 74 patients comparing vitamin B12 supplementation with 500 μg/day versus 1500 μg/day after 3 months of treatment, 8% of those on the lower dose had deficient levels versus none on the higher dose (17)