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Side effects include: Anxiety Irritability Heart issues High blood pressure Monthly Weight Loss How much weight you will lose when taking phentermine and topiramate varies from person to person and depends on a number of wide-ranging factors, according to research, such as: Age Sex Race Genetics Baseline weight Body composition Metabolic rate Co-occurring medical conditions Other medications you may take Diet quality Physical activity Sleep Hydration Psychological factors Stress You must take the medication as prescribed to get any potential weight loss benefits