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Eligibility (key inclusion criteria): Age 18–45 years Acute posterior thigh pain consistent with hamstring strain, onset within 72 hours of screening MRI-confirmed grade II hamstring strain (biceps femoris, semitendinosus, or semimembranosus) with measurable lesion Physical activity ≥3 sessions/week or organized recreational sport participation Willingness to complete all study visits and follow the standardized rehabilitation protocol Key exclusion criteria: Grade III hamstring tear, avulsion, or injury requiring surgery Prior hamstring strain on the same limb within 6 months Concomitant use of systemic corticosteroids, anabolic agents, platelet-rich plasma, stem-cell products, or investigational peptides/growth factors within 30 days Current participation in anti-doping testing programs (WADA/USADA-aligned) unless explicitly approved by the relevant authority Primary Endpoints The trial uses two co-primary endpoints: Time to return to unrestricted sport participation (days): Defined as clinician clearance combined with completion of a standardized functional performance battery without pain-limited stopping
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The clinic's in-person model provides direct access to the nurse practitioner for ongoing questions, protocol adjustments, and clinical monitoring throughout treatment
