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In the REEF-2 study, HBV DNA ≥100,000 IU/mL predicted a severe ALT flare (defined as ALT ≥10xULN) in patients who stopped NA therapy, providing a criterion for restarting antiviral therapy before the onset of a severe flare [33]

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Hoolset provides both a handheld tcVNS solution ( Verelief ) and a hands‐free headphone bilateral tcVNS ( Hoolset ) technology

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