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Sesamin reversed the elevation of ROS production and depletion of the intracellular GSH level, restored the activities of antioxidant enzymes and decreased 8-OHdG levels (marker of oxidative DNA damage), increased expression levels of PI3K and phosphorylated Akt, which in turn led to the inactivation of pro-apoptotic signaling events in the liver of nickel-treated mice [163]

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Medical Necessity and Diagnosis Codes ICD-10-CM diagnosis codes must justify the intralesional injection